From the large front door made from woven walnut wood to the more than 500 pieces of artwork by everyone from John Waters to Do-Ho Suh, the Chambers Hotel feels like a chic downtown gallery that's plopped down into the middle of New York's Midtown retail hub. In addition to the paintings that line the walls of guest rooms, hallways and other public spaces, the hotel uses warm shades of brown throughout, and the rooms have a loft-like feel with large windows and sleek furniture. Massage therapists, babysitters and even personal shoppers from Henri Bendel are a phone call away, as is room service from TOWN, the onsite Geoffrey Zakarian restaurant that has 24-foot ceilings and serves modern French food.

Chambers Amenities:

• 77 rooms. Wireless Internet access. Restaurant, bar. Pets accepted.