This 1915 Southern estate is a lovely setting for a weekend getaway, and the mansion also serves as a facility for meetings and retreats. The charming Colonial Revival house was once owned by James Buchanan Duke, founder of Duke University. Acres of gardens surround the well-maintained house. Treetop rooms as well as standard guest rooms—some with sleeping porches—are decorated with traditional and antique furniture.

The Duke Mansion Amenities:

• 20 rooms. Complimentary full breakfast. Wireless Internet access.