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In the heart of downtown Louisville on the corner of Muhammad Ali and Fourth Street (the windiest corner in the city), The Seelbach Hilton Hotel stands just steps south of the Fourth Street Live! entertainment complex, at 500 South Fourth St. Bars, restaurants, nightlife, shopping and entertainment options abound in the downtown area, with newly revitalized areas springing up on Main and Market Streets.
Three blocks away is the Kentucky International Convention Center, with the scenic River Walk along the Ohio River a half-mile northeast of the hotel. Other nearby attractions include the Yum! Center, the Muhammad Ali Center, the Louisville Slugger Museum, and the Louisville Science Center.