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A mix of rustic, industrial and modern, the Iron Horse Hotel pulls inspiration from the 100-plus-year history of the building and Milwaukee’s motorcycle culture. Although it targets business and leisure travelers equally, it is especially kind to motorcycle enthusiasts. The use of leather, reclaimed wood and metals, exposed brick and beams and rich color schemes define this uncommon six-story space. To carry home the idea that this is a Milwaukee hotel, the property features works by a handful of prominent local artists, including Charles Dwyer, whose mixed-media murals hang in each of the guest rooms.