One of the newest kids on the block—if a mega-resort with more than 3,000 rooms can be considered a kid—this sister property of the Venetian opened in January 2008 at an estimated cost of $1.9 billion. The guest rooms in the 50-story tower start at 720-square-feet and are decorated in a contemporary Italian style complete with remote-controlled Roman shades, Egyptian linens from Anichini and curtains to block out that searing desert sun. The Shoppes at Palazzo has more than 50 stores, and once you've built up an appetite from shopping, head for one of the various dining options. Celebrity chefs such as Mario Batali, Wolfgang Puck, Emeril Lagasse and Charlie Trotter have all opened signature restaurants here, bringing with them a hip crowd of hungry, happy revelers.

The Palazzo Amenities:

• 3,066 rooms, all suites. Wireless Internet access. Restaurant, bar. Airport transportation available. Fitness center. Pool. Spa. Business center.