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For a decadent afternoon of pampering, make an appointment at Remède Spa San Francisco by calling the spa directly. (Online booking isn’t offered, unfortunately.) The spa, located on the sixth floor of The St. Regis San Francisco, is one of the most luxurious in the entire Bay Area. You’ll find a full range of skin, body and nail treatments — each delivered to you with a high level of attention. From truffles and champagne in the lounge to the heavyweight fluffy robes you’ll don to your massage, no opportunity to be spoiled is ignored. Weekends are busiest, unsurprisingly, so book on a weekday or weekend evening for the most flexibility. The Forbes Travel Guide Four-Star spa's hours are 10 a.m. to 8 p.m. Monday through Thursday; 9 a.m. to 9 p.m. Friday and Saturday; and 10 a.m. to 7 p.m. Sunday.