Located inside the Sanctuary at Kiawah Island, the Spa resembles a grand Southern seaside mansion. Inside, the hospitable staff greets guests with herbal tea and fresh fruit before leading the way to one of 12 rooms for nature-based treatments, which feature botanical extracts, natural enzymes and a signature Southern touch. If exercise is on your mind, head downstairs to the fitness center, which features latest cardiovascular and resistance equipment, a 65-foot-long indoor pool and Pilates and yoga studios.