It's all about risk and return when it comes to Sin City's slots. Sure, it's fun plunking penny after penny into a fickle one-arm bandit, but if you want the biggest bang for your buck, it's time to find a high-yield slot. Denominations of $1, $5, $10, and $25 often yield higher returns, but as you know, Vegas doesn't do anything small. If you're a true high-roller, head to the Bellagio to lay down a cool $1,000 for a pull of the lever (or touch of the button, as the case may be). Typically, you want to stick with machines that have a 90 to 97 percent return rate, which means they pay back 90 to 97 cents per dollar played over the long run. (You can typically find return rates posted at casinos.) Also, most slot machines will give higher rewards for playing the maximum coins, so empty as much spare change as the machine will take in one round.

Just because these machines pay well in the long run, doesn't mean they're a sure thing, though. Luck and chance are still factors, and your odds of winning from a slot with a bigger jackpots are lower. Yet someone has to hit that big money—why can't it be you?