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It's no surprise that Sin City is home to some of the most luxurious, offbeat, energetic, indulgent nightclubs in the nation. Whatever itch you want to scratch, you'll find it in a nightclub in Las Vegas.

Dive headfirst into a high-end carnival at Tao at the Venetian (3355 Las Vegas Blvd. S., Las Vegas, 702-414-1000; www.venetian.com), a spot for celebs and seasoned night owls. A lady lounging in a bathtub filled with rose petals is the first sight you'll see, along with lingerie-clad models painting henna on each other's bodies. That is followed by an expansive, multi-barred interior decorated with Asian accents, and an elevated DJ stage pouring forth hip-hop and house music.

For a super-luxe night, head to Tryst at Wynn Las Vegas (3131 Las Vegas Blvd. S., Las Vegas, 702-770-3384; www.wynnlasvegas.com), which is outfitted in deep reds and mellow browns and dotted with private tables, semi-secluded booths, and two outdoor patios. The centerpiece of the 1,200-foot nightclub is the spacious dance floor, which opens up onto a 90-foot waterfall cascading into a secluded lagoon.

For something more low-key and exotic, skip straight to Red Square in Mandalay Bay (3950 Las Vegas Blvd. S., Las Vegas, 702-632-7407; www.mandalaybay.com). The quirky interior, with its plush red velvet seats and headless Lenin statue, is the perfect Imperial Russian backdrop for a late night of sipping cocktails and nibbling on caviar. The nightclub's vodka vault (a walk-in freezer that's open to guests) holds more than 200 frozen vodkas and infusions, for powerful martinis (espresso, raspberry, chocolate), vodka flights and Russian-inspired cocktails.

Other hot spots include JET (3400 Las Vegas Blvd. S., Las Vegas, 702-693-8300; www.mirage.com), a high-energy mega-club with a major dance scene; Hard Rock Hotel's The Joint (4455 Paradise Rd., Las Vegas, 702-693-5000; www.hardrockhotel.com), for laid back rock, though often one of the toughest tickets in town; Sand Dollar Blues Lounge (3355 Spring Mountain Rd., Las Vegas, 702-871-6651; http://sanddollarblues.com) for good drinks and great live blues acts; and Eye Candy (3950 Las Vegas Blvd. S., Las Vegas, 702-632-7777; www.mandalaybay.com), a tech-fueled dance space in a futuristic-fabulous setting. Those seeking a bit of bunny-tailed nostalgia should hop to the Playboy Club at the Palms Hotel (4321 W. Flamingo Rd., Las Vegas, 702-942-7777; www.palms.com), which mixes classy cocktails and classic costumes with a dash of dancing and poker.