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For the ultimate serene setting, you can't beat the gorgeous Mandarin Oriental Hotel whose Forbes Travel Guide Five-Star spa is a lesson in serene luxury. The modern Asian feel takes you world's away for the ultimate spa day. Spa Claremont at the iconic Claremont Hotel Resort and Spa in the Berkeley hills is the ultimate pamper break outside the city. For something different and very San Francisco, head to Kabuki Springs and Spa Japantown. This nirvana inducing desitnation offers traditional and exotic spa services (exfoliation with tumeric and ground rice), acupuncture, and its famous communal baths.