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Though nearby Union Square is rife with tourist traps, the area around Four Seasons Hotel San Francisco has a few watering holes worth seeking out. The adjacent Tropisueno has great margaritas; it’s across from Press Club, a sophisticated wine-and-small-bites stop.
A few blocks from the Five-Star hotel, you’ll find Rickhouse, where mixologists create innovative seasonal cocktails. (Avoid it around 5 p.m., when the post-work crowd swarms the place.) For dancing, head to SoMa (South of Market), where party people find a variety of gay, straight and mixed clubs. Be aware that the area has a few sketchy pockets, particularly along Sixth Street.