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Once you sink into a bed at The St. Regis San Francisco, you might have a hard time getting back up. The plush feather-top Sealy posturepedic mattress pretty much ensures a good night’s sleep, especially when you’re ensconced in Italian linens that are custom-made for the Five-Star hotel. Thick down pillows are standard here, but hypoallergenic pillows are also available upon request. Of course, the most comfortable bed in the world isn’t worth much unless it’s in a setting that’s conducive to sleep. Fortunately, the luxury hotel’s rooms are well-insulated — we couldn’t hear a single honking cab from outside, let alone our next-door neighbor. You’ll find that your room’s window shades completely block out any light, making it as easy for you to catch some z’s anytime you want.